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Sanofi Group Principal Research Associate, Cell Line Development- Framingham/MA in Framingham, Massachusetts

Cell Line Development Skill Center – Principal Research Associate

The Sanofi Cell Line Development group is seeking a highly motivated full-time employee to join a high-performing, collaborative team supporting research and preclinical development projects in Sanofi’s global R&D pipeline. The team is responsible for the expression of protein biologics from a wide variety of formats and modalities. Our environment is team-oriented, fast-paced, and challenging, and we are seeking candidates with the passion, skills, and determination to execute on our mission of generating high-quality cell lines.

Position Overview and Key Responsibilities

  • Expression vector construction and plasmid preparation

  • Generation and evaluation of recombinant CHO cell lines for preclinical development programs

  • Production and characterization of small-scale cell banks

  • Genetic characterization of production cell lines

  • Conduct studies to help improve speed of cell line development

  • Write technical reports and communicate results in project team meetings

  • Manage work assignments, analyze and interpret test results, and conduct necessary troubleshooting

  • Flexibility, adjusting to a fast-paced, goal-oriented environment

  • Good organization and communication skills; must be able to collaborate as part of a cross-functional, multi-disciplinary team and adhere to timelines

  • Lead cell line development projects end-to-end

Basic Qualifications

  • BS degree in Biologic or related sciences with 9+ years or MS degree in Biologic Sciences with 7+ years of molecular biology and mammalian cell culture experience.

  • Must be able to collaboratively work in a fast paced, team oriented environment.

  • Must be organized, efficient and able to work across several projects according to timelines to meet project goals

Preferred Qualifications

  • Hands-on experience in vector construction, suspension culture of CHO cell lines, clone isolation, flow cytometry, and genetic characterization

  • Experience in the cryopreservation and thaw of mammalian cell lines

  • Experience in the interpretation of protein analytics, such as glycoform, purity aggregation, and charge variant analysis

  • Proficient in Microsoft Word, Excel, PowerPoint, with familiarity in FloJo, Vector NTI

  • Excellent oral and written communication skills

Interested candidates should submit a resume describing their experience and technical abilities as well as a cover letter succinctly describing any aspect of their cell cloning and culture experience.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.


At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.

With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.

Sanofi, Empowering Life